心衰竭

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鬱血性心衰竭簡稱心衰竭，肇因於結構或功能的異常表現或受損，致使心臟無法滿足或輸出足夠的血量，並無法滿足身體組織、器官代謝之需求，是病態的生理狀況，也可能是任何心臟疾病最終的表現。一般而言，冠狀動脈心臟病是造成心衰竭最常見的原因之一。

唯不可將心衰竭與某些術語混淆：

• 心跳停止乃是asystole,
• cardiac arrest, which is the cessation of normal cardiac function with subsequent hemodynamic collapse leading to death. Because not all patients have volume overload at the time of initial or subsequent evaluation, the term "heart failure" is preferred over the older term "congestive heart failure".

Congestive heart failure is often undiagnosed due to a lack of a universally agreed definition and difficulties in diagnosis, particularly when the condition is considered "mild".

目录 1 發病原因 1.1 左心病變 1.2 右心病變 2 分類 3 發病跡象和症狀 3.1 左心衰竭 3.2 右心衰竭 4 治療 4.1 Non-pharmacological measures 4.2 Pharmacological management 4.2.1 Angiotensin-modulating agents 4.2.2 Diuretics 4.2.3 Beta blockers 4.2.4 Positive inotropes 4.2.5 Alternative vasodilators 4.3 儀器和外科手術 5 References in Pop Culture 6 參見 7 參考文獻 8 Footnotes 9 外部連結

[编辑] 發病原因

Causes and contributing factors to congestive heart failure include the following (with specific reference to left (L) or right (R) sides):

• Genetic family history of CHF
• Ischemic heart disease/Myocardial infarction (coronary artery disease)
• 感染
• Alcohol ingestion
• Heartworms
• 貧血
• Thyrotoxicosis (hyperthyroidism)
• 心律不整

[编辑] 左心病變

• 高血壓
• Coarctation of the 主動脈
• Aortic stenosis/regurgitation
• 僧帽瓣逆流 mitrl regurgitation
• 僧帽瓣疾病

[编辑] 右心病變

• Pulmonary stenosis、肺高壓、肺栓塞都會導致心肺症 cor pulmonale

The usual heart irritants can make CHF deadly: arterial plaque, stress, smoking, old age, lack of exercise, overworked heart, and obesity. In genetic family history of CHF, the cause is a weak heart having thinner muscle walls than usual, and often weakened further by one or more of the above heart irritants. Arterial plaque (caused by eating fatty or greasy foods) lines the inside of the arteries that supply the heart and the rest of the body, meaning less blood gets to the heart itself, as well as the heart having to work harder to push blood through the thinner systemic arteries. The result is irregular heart beats causing inefficient blood pumping and a tired heart.

[编辑] 分類

There are many different ways to categorize heart failure, including:

• the side of the heart involved, (left heart failure versus right heart failure)
• whether the abnormality is due to contraction or relaxation of the heart (systolic heart failure vs. diastolic heart failure)
• whether the abnormality is due to low cardiac output or low systemic vascular resistance (low-output heart failure vs. high-output heart failure)

The NYHA functional class is a commonly used way to gauge the progression of CHF in a particular patient. This classification is used to determine how much CHF limits their lifestyle, and does not apply to a particular decompensated episode. Depending on symptoms, patients may move in either direction on the NYHA scale.

• Class I: No symptoms at any level of exertion
• Class II: Symptoms with heavy exertion
• Class III: Symptoms with light exertion
• Class IV: Symptoms with no exertion

Heart failure stages from the ACC/AHA guidelines represent a newer classification that complements the NYHA classification.

• Stage A: At risk for developing heart failure without evidence of cardiac dysfunction
• Stage B: Evidence of cardiac dysfunction without symptoms
• Stage C: Evidence of cardiac dysfunction with symptoms
• Stage D: Symptoms of heart failure despite maximal therapy

An important feature of the staging classification is that patients can only progress in one direction: from Stage A to D. This is meant to reflect the progressive nature of heart failure.

[编辑] 發病跡象和症狀

[编辑] 左心衰竭

心臟衰竭decompensated的症狀包括氣促 dyspnea on exertion, orthopnea (dyspnea that increases upon lying down), fatigue and paroxysmal nocturnal dyspnea ("cardiac asthma", shortness of breath that occurs hours or minutes after lying down). Nocturnal cough, Confusion and memory impairment (in advanced stages), and diaphoresis and cool extremities at rest.

Signs of decompensated left heart failure include: Displaced apex beat (usually to left due to cardiomegaly), Pathologic S3 Gallop, S4, Crackles at the lung bases due to pulmonary edema (fluid accumulation in the lungs), Dullness to percussion and tactile fremitus of lower lung fields. Increased intensity of pulmonic component of 2nd heart sound.

[编辑] 右心衰竭

症狀包括週邊水腫 Peripheral edema(fluid build-up in dependent portions of the body), ascites (fluid in the abdominal cavity), nocturia (due to increased venous return with leg elevation), Jugular venous distention, Epistaxis (due to an increase in venous pressure), Hepatomegaly, hepatojugular reflux, and right ventricular heave.

Individuals with heart failure are sensitive to small shifts in their intravascular volume status (the amount of fluid in their circulatory system). Increasing the volume in their circulatory system can cause symptoms and signs of decompensated heart failure, while decreasing the volume in the circulatory system can cause hypotension.

Chest X-rays (CXRs) are frequently used to aid in the diagnosis of CHF. Signs of CHF on CXR are^[1]:

• Vascular redistribution
• Peribronchial cuffing/interstitial edema (bat-shaped)
• Kerley B lines
• Consolidation of lower lung fields
• Cardiomegaly

[编辑] 治療

The treatment of CHF focuses on treating the symptoms and signs of CHF and preventing the progression of disease. If there is a reversible cause of the heart failure (e.g. infection, alcohol ingestion, anemia, thyrotoxicosis, arrhythmia, or hypertension), that should be addressed as well. Reversible cause treatments can include exercise, eating healthy foods, reduction in salty foods, and abstinence of smoking and drinking alcohol.

[编辑] Non-pharmacological measures

Patients with CHF are educated to undertake various non-pharmacological measures to improve symptoms and prognosis. Such measures include (Smith et al., 2003):

• Moderate physical activity, when symptoms are mild or moderate; or bed rest when symptoms are severe.
• Weight reduction – through physical activity and dietary modification, as obesity is a risk factor for heart failure and ventricular hypertrophy.
• Sodium restriction – excessive sodium intake may precipitate or exacerbate heart failure, thus a "no added salt" diet (60–100 mmol total daily intake) is recommended for patients with CHF. More severe restrictions may be required in severe CHF.
• Fluid restriction – patients with CHF have a diminished ability to excrete free water load. They are also at an increased risk of hyponatremia due to the combination of decreased sodium intake and diuretic therapy. Generally water intake should be limited to 1.5 L daily or less in patients with hyponatremia, though fluid restriction may be beneficial regardless in symptomatic reduction.

[编辑] Pharmacological management

It has been noted that there is a significant evidence–practice gap in the treatment of CHF, particularly the underuse of ACE inhibitors and β-blockers. (Jackson et al., 2005) Treatment of CHF aims to relieve symptoms, maintain a euvolemic state (normal fluid level in the circulatory system), and to improve prognosis by delaying progression of heart failure and reducing cardiovascular risk. Drugs used include: diuretic agents, vasodilator agents, positive inotropes, ACE inhibitors, beta blockers, and aldosterone antagonists (e.g. spironolactone).

[编辑] Angiotensin-modulating agents

ACE inhibitor (ACEI) therapy is a recommended for all patients with systolic heart failure, irrespective of symptomatic severity or blood pressure.^[2][3] (NICE, 2003) ACE inhibitors improve symptoms, decrease mortality and reduce ventricular hypertrophy. Angiotensin II receptor antagonist therapy (also referred to as AT₁-antagonists or angiotensin receptor blockers), particularly using candesartan, is an acceptable alternative if the patient is unable to tolerate ACEI therapy.^[4][5]

[编辑] Diuretics

Diuretic therapy is indicated for the relief of congestive symptoms. Several classes are used, with combinations reserved for severe heart failure (Smith et al., 2003):

• Loop diuretics (e.g. furosemide) – most commonly used class in CHF, usually for moderate CHF.
• Thiazide diuretics (e.g. hydrochlorothiazide) – useful for mild CHF.
• Potassium-sparing diuretics (e.g. amiloride) – used first-line use to correct hypokalaemia.
  • Spironolactone is used as add-on therapy to ACEI plus loop diuretic in severe CHF.
  • Eplerenone is specifically indicated for post-MI reduction of cardiovascular risk.

[编辑] Beta blockers

Until recently, β-blockers were contraindicated in CHF, owing to their negative inotropic effect and ability to produce bradycardia – effects which worsen heart failure. However, current guidelines recommend β-blocker therapy for patients with systolic heart failure due to left ventricular systolic dysfunction after stabilization with diuretic and ACEI therapy, irrespective of symptomatic severity or blood pressure. (NICE, 2003) As with ACEI therapy, the addition of a β-blocker can decrease mortality and improve left ventricular function. Several β-blockers are specifically indicated for CHF including: bisoprolol, carvedilol, and extended-release metoprolol.

[编辑] Positive inotropes

Digoxin, once used as first-line therapy, is now reserved for control of ventricular rhythm in patients with atrial fibrillation; or where adequate control is not achieved with ACEI plus loop diuretic. There is no evidence that positive inotropes reduce mortality in CHF.

[编辑] Alternative vasodilators

The combination of isosorbide dinitrate/hydralazine is the only vasodilator regimen, other than ACE inhibitors or angiotensin II receptor antagonists, with proven survival benefits. This combination appears to be particularly beneficial in CHF patients with an African American background, who respond less effectively to ACEI therapy.^[6][7]

[编辑] 儀器和外科手術

Patients with NYHA class III or IV, left ventricular ejection fraction (LVEF) of 35% or less and a QRS interval of 120 ms or more may benefit from cardiac resynchronization therapy (CRT; pacing both the left and right ventricles), through implantation of an bi-ventricular pacemaker, or surgical remodelling of the heart. These treatment modalities may make the patient symptomatically better, improving quality of life and in some trials have been proven to reduce mortality.

The COMPANION trial demonstrated that CRT improved survival in individuals with NYHA class III or IV heart failure with a widened QRS complex on EKG.^[8] The CARE-HF trial showed that patients receiving CRT and optimal medical therapy benefited from a 36% reduction in all cause mortality, and a reduction in cardiovascular-related hospitalization.^[9]

Patients with NYHA class II, III or IV, and LVEF of 35% (without a QRS requirement) may also benefit from an implantable cardioverter-defibrillator (ICD), a device that is proven to reduce all cause mortality by 23% compared to placebo. This mortality benefit was observed in patients who were already optimally-managed on drug therapy.^[10]

Another current treatment involves the use of left ventricular assist devices (LVADs). LVADs are battery-operated mechanical pump-type devices that are surgically implanted on the upper part of the abdomen. They take blood from the left ventricle and pump it through the aorta. LVADs are becoming more common and are often used by patients who have to wait for heart transplants.

The final option, if other measures have failed, is cardiac transplant surgery (heart transplant) or implantation of an artificial heart.

[编辑] References in Pop Culture

• Denny Duquette on the television show Grey's Anatomy had congestive heart failure.

Wrestling Icon Andre The Giant was believed to have died from congestive heart failure on January 27, 1993

[编辑] 參見

• Cardiogenic shock
• 心臟移植
• Ventricular Restoration: The Dor Procedure
• ACE inhibitor
• Isosorbide dinitrate/hydralazine
• Killip class
• Ventricular remodeling

[编辑] 參考文獻

[编辑] Footnotes

• Donatelle RJ. Health: The basics, 6th edition. San Francisco: Pearson Education; 2005.
• Jackson S, Bereznicki L, Peterson G. Under-use of ACE-inhibitor and β-blocker therapies in congestive cardiac failure. Australian Pharmacist 2005;24(12):936.
• National Institute for Clinical Excellence. Chronic heart failure: management of chronic heart failure in adults in primary and secondary care. Clinical Guideline 5. London: National Institute for Clinical Excellence; 2003 Jul. Available from: www.nice.org.uk/pdf/CG5NICEguideline.pdf
• Smith A, Aylward P, Campbell T, et al. Therapeutic Guidelines: Cardiovascular, 4th edition. North Melbourne: Therapeutic Guidelines; 2003. ISSN 1327-9513

[编辑] 外部連結

• Congestive Heart Failure information from Seattle Children's Hospital Heart Center

• www.heartfailure-europe.com Patient information website of SHAPE (Study Group on Heart failure Awareness and Perception in Europe)